The Computational Mechanics of Bone Tissue by Unknown

Author:Unknown
Language: eng
Format: epub
ISBN: 9783030375416
Publisher: Springer International Publishing

Drug dosage

mg

Administration time interval

day

Drug elimination rate

day

Drug absorption rate

day

F

Bioavailability

–

Volume distribution

L

Drug concentration for 50% of maximum effect

mg/L

2.3.2 Models for Tumor Treatment

The models proposed in [2] also allowed for tumor treatment. Since proteasome inhibitors are known to have direct anti-myeloma effects and to have direct effects on osteoblasts to stimulate osteoblast differentiation and bone formation, two time-dependent treatment step functions, and , were introduced to model the inhibition of the osteoblasts apoptosis and tumor cells death, respectively. As such, Eqs. (6b) and (6c) are replaced by Eqs. (14a) and (14b), respectively, with and affecting the suitable parameters. This model including treatment is therefore composed of Eqs. (6a), (14a), (14b), and (6d), resulting in an increase of bone mass and the elimination of tumor.

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